Pune University Metabolic Pathway Engineering ( PuMPE ) Resource

PuMPE is a comprehensive resource that provides integrated information on metabolome of bacterial systems. The genome data is annotated to infer metabolic pathways using in-house tools and web-based sources. PuMPE introduces a novel aspect of metabolic categorization. It is the first resource to provide metabolome-based tree computed by comparing metabolome between bacteria. PuMPE has metabolic pathways information for 581 bacteria having completely sequenced genome. Information on Km (Michaelis constant) values, catalytic site data and 3D structures of enzymes is integrated and made available on one platform. Open source relational database management system MySQL is used at the backend and software used for visualization of structures and pathway interactions are also from open source. Updation is done regularly with minimal human intervention. This resource is user friendly and provides unique integrated information to carry out metabolic pathway engineering. It is available at http://115.111.37.202/mpe/ Keywords— Metabolic pathways database, pathways interactions, metabolome-based tree, metabolic categorization